-transparent.png){kind=logo}
The efficacy of 3,4,3-LIHOPO, a siderophore analogue, has been tested for removing 238Pu from rat after inhalation of plutonium as the tri-N-butylphosphate (TBP) complex. The amounts of Pu retained in the lung of untreated rat, 7 days after exposure ranged from 0.86 to 37 kBq. The results have been compared with DTPA, the current therapy of choice for man. The ligand 3,4,3-LIHOPO was more effective than DTPA for removing Pu from the body when repeated treatment began 1 h after inhalation. This observation was independent of the mass of Pu deposited in the lungs. The efficacy of 3,4,3-LIHOPO was mainly due to the decrease of Pu retention in lung, 1.5 times less than after DTPA administration; in liver and skeleton, retention was about four times less. Seven days after internal contamination, < 10% of the activity was found in organs other than lung when rat was treated with 3,4,3-LIHOPO. As this ligand showed an apparent lack of irreversible toxicity, it is likely to be of interest in the development of new decorporation treatments after inhalation of Pu as a TBP complex.
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
October 1995,
International journal of radiation biology,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
January 2000,
International journal of radiation biology,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
December 1995,
International journal of radiation biology,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
January 2003,
Radiation protection dosimetry,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
September 1985,
Health physics,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
September 1990,
Gigiena i sanitariia,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
February 1995,
Human & experimental toxicology,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
July 1996,
International journal of radiation biology,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
July 1993,
International journal of radiation biology,
J L Poncy, and
G Rateau, and
R Burgada, and
T Bailly, and
Y Leroux, and
K N Raymond, and
P W Durbin, and
R Masse
October 1992,
International journal of radiation biology,
