-transparent.png){kind=logo}
To more fully understand the role of sex hormone-binding globulin (SHBG) on the intracellular steroidal action in endometrial cancers, we investigated the expression of SHBG mRNA as the substitute of SHBG expression in human endometrial cancers. In the present study, the levels of SHBG mRNA were analyzed using competitive reverse transcription-polymerase chain reaction (RT-PCR)-Southern-blot analysis. The higher level of SHBG mRNA tended to be expressed in the normal secretory and late proliferative phase endometrium > early proliferative phase endometrium > well differentiated adenocarcinoma of the endometrium (G1) > moderately differentiated adenocarcinoma (G2) > poorly differentiated adenocarcinoma (G3), in the order shown. These studies indicate that endometrial cancer cells might synthesize intracellular SHBG to conserve their estrogen-dependent properties. Further, it indicates that endometrial cancer cell synthesis of SHBG mRNA is lost as these cells undergo de-differentiation.
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
December 1994,
European journal of endocrinology,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
February 1994,
European journal of endocrinology,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
January 1998,
Molecular endocrinology (Baltimore, Md.),
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
April 2004,
Molecular and cellular endocrinology,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
July 1992,
The Journal of clinical endocrinology and metabolism,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
December 2001,
The Biochemical journal,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
January 1999,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
November 1983,
Ugeskrift for laeger,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
January 1974,
Clinical endocrinology,
R Misao, and
Y Nakanishi, and
S Ichigo, and
M Hori, and
J Fujimoto, and
T Tamaya
January 1982,
Medicina,
