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The effect of a low concentration of glucose on prostacyclin (PGI2) production by human umbilical vein endothelial cells in culture (HUVEC) was examined. When HUVEC were cultured for 24 h in a medium containing various concentrations of glucose (0.26, 0.63, or 1.29 mg/ml), thrombin-induced PGI2 production was increased in the cells exposed to low concentrations of glucose; the increase was inversely proportional to the glucose concentration and was seen at all concentrations of thrombin tested. Thus, hypoglycemia may increase the production of PGI2 by endothelial cells in vivo, leading to a compensatory vasodilation with an increase in blood flow to increase the delivery of glucose.
K Watanabe, and
E A Jaffe
October 1990,
Metabolism: clinical and experimental,
K Watanabe, and
E A Jaffe
May 1996,
Immunology,
K Watanabe, and
E A Jaffe
June 1996,
Cellular signalling,
K Watanabe, and
E A Jaffe
August 1986,
The Journal of biological chemistry,
K Watanabe, and
E A Jaffe
September 1993,
Prostaglandins, leukotrienes, and essential fatty acids,
K Watanabe, and
E A Jaffe
May 2002,
Biochemical and biophysical research communications,
K Watanabe, and
E A Jaffe
April 2011,
Journal of immunology (Baltimore, Md. : 1950),
K Watanabe, and
E A Jaffe
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American journal of physiology. Cell physiology,
K Watanabe, and
E A Jaffe
December 1998,
The Journal of physiology,
K Watanabe, and
E A Jaffe
August 1995,
Thrombosis research,
