-transparent.png){kind=logo}
Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 have been shown to stimulate the synthesis of acute-phase proteins; however, few studies have examined the effect of these cytokines on gluconeogenesis. We investigated the effects of these cytokines on gluconeogenesis in primary cultures of rat hepatocytes. Incubation of hepatocytes for 24 hours with TNF-alpha or IL-1 alpha did not affect gluconeogenesis. Hepatocytes incubated with 100 pmol/L and 1 nmol/L IL-6 had a dose-dependent increase (P < .05) in gluconeogenesis (2.6 +/- 0.1 and 3.2 +/- 0.1 pmol/10(6) cells/min, respectively) as compared with controls (2.0 +/- 0.1).
Related Publications
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
February 2000,
Journal of biochemistry,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
March 2019,
Experimental and therapeutic medicine,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
July 1992,
Japanese journal of pharmacology,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
January 1990,
Methods in molecular biology (Clifton, N.J.),
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
January 1989,
Endocrinology,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
October 1985,
FEBS letters,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
March 1992,
Endocrinology,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
July 1996,
The Biochemical journal,
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
January 2006,
Methods in molecular biology (Clifton, N.J.),
D Blumberg, and
S Hochwald, and
M F Brennan, and
M Burt
January 2006,
Methods in molecular biology (Clifton, N.J.),
