Biomaterial Database

Analysis of heroin drug seizures by Micellar Electrokinetic Capillary Chromatography (MECC). 1995

J A Walker, and S T Krueger, and I S Lurie, and H L Marché, and N Newby

Drug Enforcement Administration, Mid-Atlantic Laboratory, Washington, D.C.

A rapid procedure using Micellar Electrokinetic Capillary Chromatography (MECC) is presented for the quantitation of illicit heroin samples. This analytical system resolves heroin from accompanying impurities and adulterants enabling accurate quantitation via the use of an internal standard. An aqueous run buffer consisting of 40 mmol sodium dodecyl sulfate, 8.5 mmol sodium phosphate, 8.5 mmol sodium borate and 15% acetonitrile is used with a 27 cm x 50 microns fused silica capillary column. Linearity, accuracy and reproducibility studies of heroin using this method are established. Comparisons to a commonly used gas chromatographic method show excellent correlation. Due to its high resolution and speed, this MECC system also serves as a screening procedure to detect impurities and adulterants present in heroin samples. Relative migration times of various opiates and adulterants are reported. With minor exceptions, complete separation of numerous compounds is achieved within five minutes, including compounds that are difficult to analyze by gas chromatography such as morphine, O6-acetylmorphine, aspirin and salicylic acid.

UI	MeSH Term	Description	Entries
D012015	Reference Standards	A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.	Standard Preparations,Standards, Reference,Preparations, Standard,Standardization,Standards,Preparation, Standard,Reference Standard,Standard Preparation,Standard, Reference
D002849	Chromatography, Gas	Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.	Chromatography, Gas-Liquid,Gas Chromatography,Chromatographies, Gas,Chromatographies, Gas-Liquid,Chromatography, Gas Liquid,Gas Chromatographies,Gas-Liquid Chromatographies,Gas-Liquid Chromatography
D003932	Heroin	A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)	Diacetylmorphine,Diamorphine,Diacetylmorphine Hydrochloride,Diagesil,Diamorf,Heroin Hydrochloride,Min-I-Jet Morphine Sulphate,Hydrochloride, Diacetylmorphine,Hydrochloride, Heroin,Min I Jet Morphine Sulphate
D004335	Drug and Narcotic Control	Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.	Drug Regulations,Narcotic Control,Pharmaceutical Policy,Drug Control,Narcotic and Drug Control,Pharmaceutic Policy,Control, Drug,Control, Narcotic,Controls, Drug,Controls, Narcotic,Drug Controls,Drug Regulation,Narcotic Controls,Pharmaceutical Policies,Policies, Pharmaceutical,Policy, Pharmaceutical,Regulation, Drug,Regulations, Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man