Biomaterial Database

Functional capillary organization in striated muscle. 1995

B R Berg, and I H Sarelius

Department of Biophysics, School of Medicine and Dentistry, University of Rochester, New York 14642.

In striated muscle, capillaries occur as independent network groups. Network architecture was quantitated in cremaster muscle of pentobarbital sodium-anesthetized hamsters in three age groups [51 +/- 1 (SE), 65 +/- 1, and 79 +/- 1 days old]. We observed that networks consist of independent subgroups of capillaries, called modules. Module architecture did not vary significantly with age during maximal dilation (Max, 10(-4) M adenosine): tissue area (A) = 1.87 +/- 0.16, 1.19 +/- 0.13, and 1.81 +/- 0.3 x 10(5) microns 2; total segment length (sigma L) = 3.07 +/- 0.23, 2.15 +/- 0.21, and 3.02 +/- 0.45 x 10(3) microns; and segment number (N) = 14.5 +/- 1.1, 9.9 +/- 1.1, and 12.6 +/- 1.6, at ages 51, 65, and 79 days, respectively. Max module architecture was not different at 65 days of age at a second site of known higher O2 inflow: A = 2.03 +/- 0.32 x 10(5) microns 2; sigma L = 3.07 +/- 0.47 x 10(3) microns; and N = 13.1 +/- 2.1. During control conditions (Rest) there was also no significant difference with age: A = 1.68 +/- 0.18, 1.15 +/- 0.19, and 1.64 +/- 0.24 x 10(5) microns 2; sigma L = 2.31 +/- 0.23, 1.91 +/- 0.33, and 2.82 +/- 0.37 x 10(3) microns; N = 10.2 +/- 1.0, 7.8 +/- 1.3, and 11.0 +/- 1.4, at ages 51, 65, and 79 days, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008647	Mesocricetus	A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research.	Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D001783	Blood Flow Velocity	A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.	Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D002196	Capillaries	The minute vessels that connect arterioles and venules.	Capillary Beds,Sinusoidal Beds,Sinusoids,Bed, Sinusoidal,Beds, Sinusoidal,Capillary,Capillary Bed,Sinusoid,Sinusoidal Bed
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D018482	Muscle, Skeletal	A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.	Anterior Tibial Muscle,Gastrocnemius Muscle,Muscle, Voluntary,Plantaris Muscle,Skeletal Muscle,Soleus Muscle,Muscle, Anterior Tibial,Muscle, Gastrocnemius,Muscle, Plantaris,Muscle, Soleus,Muscles, Skeletal,Muscles, Voluntary,Skeletal Muscles,Tibial Muscle, Anterior,Voluntary Muscle,Voluntary Muscles
D024510	Muscle Development	Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.	Myofibrillogenesis,Myogenesis,Muscular Development,Development, Muscle,Development, Muscular