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Thirty-eight cases of pancreatic duct cell carcinoma were examined for p53 expression and proliferating cell nuclear antigen (PCNA) by enhanced immunohistochemistry, as well as for changes in numbers of argyrophilic nucleolar organizer regions (AgNORs). Fifteen cases (39.5%) showed p53 overexpression, which tended to increase in proportion to the histopathological grading of malignancy. However, tumor stage and lymph node status were not correlated to p53 overexpression. PCNA labeling index (LI) increased with both histologically malignant grading and pathological stage, but was not correlated with lymph node status. The expression of p53 and PCNA thus did not necessarily reflect the degree of malignant development. In contrast, AgNOR number showed statistically significant correlations with these three indicators of malignancy. A comparative analysis of p53, PCNA LI and AgNOR number showed overexpression of p53 to be correlated to PCNA LI and essentially unrelated to AgNOR number. The present results thus indicate a close relation between p53 and PCNA, while AgNORs appear to be regulated separately from either of them.
T Suzuki, and
Y Takano
August 2002,
Gynecologic oncology,
T Suzuki, and
Y Takano
January 1997,
Oncology reports,
T Suzuki, and
Y Takano
May 1998,
International journal of molecular medicine,
T Suzuki, and
Y Takano
September 1998,
Journal of surgical oncology,
T Suzuki, and
Y Takano
October 1993,
Cancer research,
T Suzuki, and
Y Takano
January 1994,
Anticancer research,
T Suzuki, and
Y Takano
January 1999,
Oral oncology,
T Suzuki, and
Y Takano
January 2000,
Anticancer research,
T Suzuki, and
Y Takano
April 1995,
British journal of urology,
T Suzuki, and
Y Takano
October 1995,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
