-transparent.png){kind=logo}
The effects of three months therapy with Pentoxifylline (800 mg three times daily) and physical training were compared in two age- and sex-matched groups of Stage II PAOD patients. Before therapy and after 12 and 13 weeks each patient underwent a standard treadmill test. The maximum walking time, TcPO2 half recovery time to basal values after the induced ischaemia, granulocyte production of free radicals (by the superoxide dismutase-inhibitable reduction of ferricytochrome) and surface expression of the CD11/CD18 complex of adhesion molecules (by using specific monoclonal antibodies) were determined. Pentoxifylline inhibited free radical production and reduced the percentage of granulocytes expressing adhesion receptors while exercise had no significant effect on these parameters. These changes, which reflect improved microcirculatory functioning, were associated with a greater walking capacity and shorter half recovery time (+14% vs exercise group, p < 0.01; -39% vs exercise group, p < 0.01 respectively).
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
April 1997,
Angiology,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
January 1979,
Current medical research and opinion,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
January 1986,
Current medical research and opinion,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
December 2023,
Deutsches Arzteblatt international,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
May 2005,
MMW Fortschritte der Medizin,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
January 2016,
La Revue du praticien,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
November 1999,
Zeitschrift fur arztliche Fortbildung und Qualitatssicherung,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
August 2007,
VASA. Zeitschrift fur Gefasskrankheiten,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
January 1988,
Journal of medicine,
G Ciuffetti, and
R Paltriccia, and
R Lombardini, and
G Lupattelli, and
L Pasqualini, and
E Mannarino
August 2003,
VASA. Zeitschrift fur Gefasskrankheiten,
