-transparent.png){kind=logo}
We hypothesized that the altered immunoglobulin synthesis and/or lymphocyte function apparent in patients with IgA nephropathy might be, at least partially, genetically determined. To address this hypothesis, immunoglobulin production by peripheral blood mononuclear cells in 22 patients with IgA nephropathy and 44 of their first degree relatives was investigated. Spontaneous overproduction of IgA1 and IgM from patients' PBMC was found. After pokeweed mitogen stimulation, both patients and relatives produced significantly more IgA1 and IgM than normal subjects. However, relatives showed a higher index of stimulation by pokeweed mitogen compared to both normals and patients. No differences were revealed in IgA2 or IgG subclass production among the groups. We propose that patients with IgAN have defects in immunoregulation that likely depend upon the genetic substrate in the patients' relatives. Such defect may reside not with the balance between help for and suppression of a particular isotype, but rather with the overall balance of isotypes in response to a particular antigenic challenge.
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
June 1986,
Hiroshima journal of medical sciences,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
October 1991,
Clinical nephrology,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
December 1987,
Seminars in nephrology,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
May 1982,
Clinical immunology and immunopathology,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
March 1985,
Clinical nephrology,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
December 1992,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
January 1985,
American journal of nephrology,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
October 1988,
Clinical and experimental immunology,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
June 1986,
Kidney international,
V Scivittaro, and
E Ranieri, and
M Di Cillo, and
L Aventaggiato, and
S N Emancipator, and
F P Schena
September 2013,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
