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The mutagenic effect of griseofulvin was demonstrated in a wing somatic mosaicism test (SMART) in different Drosophila lines. The mutagenic effect of this agent is accompanied by a pronounced toxic effect on Drosophila larvae and by a teratogenic effect, which is manifested in the reduction of ommatidia, phenocopying the mutation ey (eyeless-4:2.0). A relationship was shown between the level of the phenocopies and the dose of griseofulvin (GF), the genotypes of the treated larvae, the interval and duration of GF exposure, and also sexual differences. The lowest level of phenocopies is recorded for the line developed on the basis of the mutagen-sensitive mutation mus(2)201G1, which blocks excision repair.
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
February 1995,
Genetika,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
May 1990,
Genetika,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
February 1982,
Mutation research,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
April 1995,
Genetika,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
January 1981,
Genetika,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
November 1992,
Mutagenesis,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
January 1981,
Chromosoma,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
May 1981,
Mutation research,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
September 1999,
Mutation research,
O A Isaenko, and
T B Romashkina, and
P Ia Shvartsman, and
L F Shelomova
January 1981,
Genetics,
