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Pharmacokinetics of the enantiomers of tertatolol in the rat after oral and intravenous administration. 1994
T Lave, and
C Efthymiopoulos, and
B Van Overloop, and
A Gairard, and
O Crambes, and
J C Koffel, and
L Jung
Département de Chimie Thérapeutique, Faculté de Pharmacie, Illkirch-Graffenstaden, France.
1. Plasma concentrations of the two enantiomers of tertatolol were determined by gc/ms. Deuterium labelling of one of the tertatolol enantiomers was used for chiral discrimination. 2. No isotope effects were observed following simultaneous oral administration of tertatolol and [2H9]tertatolol. 3. After intravenous administration of the pseudoracemate or of each enantiomer separately, (+)-tertatolol showed a lower total clearance and volume of distribution, compared to the (-) enantiomer. 4. After oral administration of the pseudoracemate or of each enantiomer separately, no substantial difference in bioavailability were observed between the enantiomers.
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