-transparent.png){kind=logo}
[Synthesis of 4-methyl-5-substituted phenoxy-primaquine analogues and preliminary evaluation on their antimalarial activity]. 1994
Institute of Microbiology and Epidemiology, Academy of Military Medical Science, Beijing.
On basis of our previous work, seven 4-methyl-5-substituted phenoxy-6-methoxy-8-(1-methyl-4-amino-butylamino)-quinolines (II2-8) were synthesized and their antimalarial activities were preliminarily evaluated. The target compounds were prepared from 2-nitro-4-methoxy-5-bromo-acetanilide as previously described. The structures of II2-8 and all of the unknown intermediates were confirmed by elementary and spectral analyses. Preliminary biological evaluation revealed that all of II2-8 exhibited significant blood schizonticidal activity and were 4-8 times as effective as primaquine in causal prophylactic test in mice.
Related Publications
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
November 1985,
Journal of medicinal chemistry,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
January 1998,
Yao xue xue bao = Acta pharmaceutica Sinica,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
December 1985,
Journal of medicinal chemistry,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
October 2011,
Journal of medicinal chemistry,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
January 1991,
Yao xue xue bao = Acta pharmaceutica Sinica,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
April 1987,
FEBS letters,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
March 2009,
Acta pharmaceutica (Zagreb, Croatia),
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
January 2012,
Nucleosides, nucleotides & nucleic acids,
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
June 2021,
Molecules (Basel, Switzerland),
B H Zhong, and
R X Deng, and
Y L Shi, and
G F Li, and
J X Zhong, and
J D Yang, and
J Wang
September 1977,
Journal of medicinal chemistry,
