-transparent.png){kind=logo}
We determined the effect of a centrally administered V1 receptor antagonist of arginine vasopressin on the brain water content in an animal model of vasogenic brain edema. Using adult rats, a cold injury was induced in the left hemisphere of the brain by applying a frozen copper rod. 50 ng of V1 receptor antagonist was administered into the left lateral ventricle 10 minutes prior to and/or 1 hour after injury. Twenty four hours after the cold injury, the brain water and sodium contents and plasma osmolality were measured. The V1 receptor antagonist significantly suppressed the increase of the brain water and sodium contents in the cortical structure adjacent to the lesion without any changes in plasma osmolality. Our results demonstrate the effectiveness of a V1 receptor antagonist of vasopressin on vasogenic brain edema.
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
January 1997,
Acta neurochirurgica. Supplement,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
January 1999,
Neurosurgery,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
August 1992,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
January 1975,
Blood vessels,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
August 1998,
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
December 2020,
Brain research bulletin,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
January 2015,
PloS one,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
January 2018,
Turkish neurosurgery,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
December 1992,
Stroke,
S Nagao, and
M Kagawa, and
I Bemana, and
T Kuniyoshi, and
T Ogawa, and
Y Honma, and
H Kuyama
January 1990,
Journal of basic and clinical physiology and pharmacology,
