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The influence of multiple doses of vinpocetine (10 mg three times daily) on the steady state plasma concentrations of oxazepam (10 mg three times daily) was studied in 16 healthy subjects. The mean (+/- s.d.) AUC (ng ml-1h-1) of oxazepam over 24 h during combined treatment was 4716 +/- 2296 and for oxazepam treatment alone it was 4737 +/- 2448 (95% confidence intervals for ratio of means = 95.4-103.7%). The degree of plasma protein binding of oxazepam was 98.11 +/- 0.32% and was not affected by vinpocetine. Independent of vinpocentine treatment a significant diurnal change in the plasma binding of oxazepam was observed; the free drug fraction was 20% higher during the night than during the day. Cmax and AUC values based on total oxazepam in plasma were 10% lower during the night. The results indicate a lack of influence of vinpocetine on oxazepam kinetics. Diurnal changes in the plasma binding of oxazepam probably have no clinical consequences.
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
January 2000,
Journal of clinical pharmacology,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
September 1985,
Clinical pharmacology and therapeutics,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
February 1993,
Therapeutic drug monitoring,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
July 1998,
AIDS (London, England),
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
November 1998,
Journal of clinical pharmacology,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
October 1987,
Journal of clinical psychopharmacology,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
February 1998,
The Annals of pharmacotherapy,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
June 1995,
American journal of therapeutics,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
December 2005,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
G Storm, and
B Oosterhuis, and
F A Sollie, and
H W Visscher, and
W Sommer, and
H Beitinger, and
J H Jonkman
May 1996,
International journal of clinical pharmacology and therapeutics,
