-transparent.png){kind=logo}
OBJECTIVE To investigate the effect of omeprazole on the pharmacokinetics of mexiletine. METHODS Nine healthy male Japanese volunteers participated in a crossover study. On day 1, the subjects received mexiletine 200 mg. On days 2-7, they received omeprazole 40 mg, and on day 8 they received mexiletine 200 mg and omeprazole 40 mg concomitantly. Serum concentrations of mexiletine were determined just before drug administration and at 1, 2, 3, 4, 6, 8, 12, and 24 hours on day 1 and day 8. RESULTS No differences in mexiletine concentrations were observed between the two phases of the study. The mean AUCs after administration of mexiletine alone and in combination with omeprazole 40 mg/d were 6.26 and 6.20 ng.h/L, respectively. CONCLUSIONS These findings suggest that omeprazole does not affect mexiletine metabolism.
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
January 1996,
European journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
May 2002,
Clinical pharmacology and therapeutics,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
October 2006,
Journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
November 1996,
Journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
March 2002,
Journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
July 2000,
Clinical pharmacology and therapeutics,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
September 1999,
British journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
January 2000,
Journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
August 1994,
British journal of clinical pharmacology,
M Kusumoto, and
K Ueno, and
K Tanaka, and
K Takeda, and
K Mashimo, and
T Kameda, and
Y Fujimura, and
M Shibakawa
September 1985,
Clinical pharmacology and therapeutics,
