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We investigated the inhibitory effects of neopterin (NP) and its reduced form, 5,6,7,8-tetrahydroneopterin (NPH4), on carbon tetrachloride (CCl4)-induced hepatotoxicity. In in vivo experiments, intraperitoneal administration of NP or NPH4 significantly inhibited the elevation of plasma alanine aminotransferase activity induced by CCl4 in mice. In in vitro experiments using cultured rat hepatocytes, CCl4 induced in a manner which was both time- and dose-dependent lactate dehydrogenase release, and the addition of NP or NPH4 to the culture-medium significantly inhibited its release from cells. NPH4, but not NP, reacted directly with a stable radical, 1,1-diphenyl-2-picrylhydrazyl. These results suggest that NP and NPH4 inhibit CCl4-induced hepatotoxicity through different mechanisms.
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
April 1986,
Research communications in chemical pathology and pharmacology,
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
January 2001,
Zeitschrift fur Naturforschung. C, Journal of biosciences,
T Icho, and
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K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
May 1990,
The Journal of toxicological sciences,
T Icho, and
S Kojima, and
K Yoshikawa, and
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M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
January 1979,
Toxicology and applied pharmacology,
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
December 1988,
Journal of applied toxicology : JAT,
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
October 1979,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
June 1967,
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T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
March 1993,
Journal of biochemical toxicology,
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
October 2006,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Icho, and
S Kojima, and
K Yoshikawa, and
T Yoshimura, and
M Shirota, and
Y Kajiwara, and
K Kitabatake, and
K Kubota
November 1995,
Drug and chemical toxicology,
