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Previous studies have shown that morphine stimulates simian immunodeficiency virus (SIV) replication in SIV-infected human CEM x174 cells as well as in monkey lymphocytes through a mechanism of delaying the lysis of infected cells (Biochem. Biophys. Res. Commun. 195:1165-1173, 1993). The present study describes the identification of brain-like opioid receptor sequences in RNA transcripts of both CEM x174 cells and monkey lymphocytes. Study of the gene sequence of a lymphocyte opioid receptor encompassing the third transmembrane domain and the third cytoplasmic loop indicates a 96% homology in amino acid composition to the delta opioid receptor in brain cells. Expression of such an opioid receptor sequence in lymphocytic cells is constitutive, since it could be detected in both saline-treated and morphine-treated monkeys as well as in morphine-treated monkeys after detoxification.
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
December 1993,
Molecular pharmacology,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
June 1996,
Neuroreport,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
August 1997,
European journal of pharmacology,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
April 2008,
Biochemical and biophysical research communications,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
August 1999,
The Journal of biological chemistry,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
June 1996,
Neuroscience,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
November 2001,
The Journal of biological chemistry,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
February 1995,
Biochemical and biophysical research communications,
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
December 1992,
Science (New York, N.Y.),
L F Chuang, and
T K Chuang, and
K F Killam, and
A J Chuang, and
H F Kung, and
L Yu, and
R Y Chuang
November 1992,
Biochemical pharmacology,
