-transparent.png){kind=logo}
The anticonvulsive activity of three kinds of pyrazolidinones: 5-benzyl-substituted-3-pyrazolidinones; 5-benzyl-1-alkyl substituted and 1-alkyl substituted-3-pyrazolidinones were studied. Fourteen substitutes of these three kinds of pyrazolidinones were found to be potent anticonvulsants. In doses less than TD50, they were found to be able to protect mice and rats from seizures produced by maximal electroshock seizure (MES), such action appeared rapidly and lasted for a short period. II-f was shown to be the most potent anti-MES agent among these three kinds of pyrazolidinones. It also showed therapeutic effect in treating experimental epilepsy produced by intrahippocampal injection of zinc sulfate in rabbits and audiogenic seizures in rats. The third kind of pyrazolidinones also showed anti-metrazol induced seizures in mice.
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1990,
Yao xue xue bao = Acta pharmaceutica Sinica,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1966,
Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1966,
Izvestiia na Instituta po fiziologiia,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1966,
Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1970,
European neurology,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1976,
Zhurnal eksperimental'noi i klinicheskoi meditsiny,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1964,
Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1965,
Izvestiia na Instituta po fiziologiia,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
January 1965,
Izvestiia na Instituta po fiziologiia,
J F Liu, and
Y Q Pei, and
Z D Wang, and
J G Xu, and
X P Lei, and
Y Z Ling
February 1995,
Neuroreport,
