BIOMAT Database Logo BIOMAT Database Logo

[Combined action of juvenile hormone and ecdysterone on Drosophila cell lines in vitro]. 1975

A M Courgeon

The action of juvenile hormone used alone or combined with ecdysterone was studied on in vitro diploid cell lines or clones of Drosophila. The solubility of juvenile hormone in the culture medium was estimated to be 10(-8) M. At this concentration, which can be considered as physiological, juvenile hormone slows down the process of ecdysone-induced morphological modifications of the cells. This action is reversible. Concentrations of about 10(-4) M inhibit all reactions to ecdysterone and bring about the death of the cells. This effect is probably non-specific.

UI MeSH Term Description Entries
D007605 Juvenile Hormones Compounds, either natural or synthetic, which block development of the growing insect. Insect Growth Regulator,Insect Growth Regulators,Juvenile Hormone,Growth Regulators, Insect,Regulators, Insect Growth,Growth Regulator, Insect,Hormone, Juvenile,Hormones, Juvenile,Regulator, Insect Growth
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002782 Cholestenes Steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.
D004331 Drosophila melanogaster A species of fruit fly frequently used in genetics because of the large size of its chromosomes. D. melanogaster,Drosophila melanogasters,melanogaster, Drosophila
D004441 Ecdysterone A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE. 20-Hydroxyecdysone,Beta-Ecdysone,Crustecdysone,20 Hydroxyecdysone,Beta Ecdysone
D000963 Antimetabolites Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033) Antimetabolite

Related Publications

A M Courgeon
Effect of ecdysterone on ethyl trimethyl dodecadienoate juvenile hormone action in Oncopeltus fasciatus.
June 1974, Journal of insect physiology,
A M Courgeon
Synergistic effect of ecdysterone on morphogenetic activity of juvenile hormone analogues.
August 1972, Life sciences. Pt. 2: Biochemistry, general and molecular biology,
A M Courgeon
Genetic tools to study juvenile hormone action in Drosophila.
May 2017, Scientific reports,
A M Courgeon
Paralogous genes involved in juvenile hormone action in Drosophila melanogaster.
August 2010, Genetics,
A M Courgeon
Influence of ecdysterone on the growth of cells and synthesis of macromolecules in established cell lines of Drosophila melanogaster.
January 1975, The Soviet journal of developmental biology,
A M Courgeon
Drosophila Met and Gce are partially redundant in transducing juvenile hormone action.
December 2011, Insect biochemistry and molecular biology,
A M Courgeon
Morphogenetic effects of juvenile hormone and juvenile hormone mimics on adult development of Drosophila.
February 1973, Journal of insect physiology,
A M Courgeon
Feedback control of juvenile hormone synthesis in cockroaches: possible role for ecdysterone.
February 1980, Science (New York, N.Y.),
A M Courgeon
In vitro metabolism of juvenile hormone III and juvenile hormone III bisepoxide by Drosophila melanogaster and mammalian cytosolic epoxide hydrolase.
April 1991, Archives of biochemistry and biophysics,
A M Courgeon
Effects and interactions of juvenile hormone and beta-ecdysone on Drosophila imaginal discs cultured in vitro.
November 1973, Developmental biology,
Copied contents to your clipboard!