BIOMAT Database Logo BIOMAT Database Logo

New international reference preparation for proteins in human serum (RPPHS). 1994

J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
Institute for Cancer Studies, St. James's University Hospital, Leeds, UK.

Quality-control surveys in recent years, in various parts of the world, have shown poor between-laboratory agreement for measurements of plasma proteins. Despite the existence of international reference materials distributed by the World Health Organization, standards produced by diagnostics manufacturers and professional organizations differ significantly in their ascribed values. The reasons for this are complex but include poor availability of the primary materials, confusion about their use, and the fact that their turbidity on reconstitution precludes their use in modern optical immunoassays. This unfortunate situation led to an important initiative to produce sufficient quantities of a widely available, optically clear secondary reference material for plasma proteins that could be used worldwide by manufacturers, professional organizations, and laboratories. Here we present an overview on how the laboratory community, including manufacturers, clinical laboratories, professional societies, and regulators, has reached what we consider is a successful conclusion to a difficult problem.

UI MeSH Term Description Entries
D007391 International Cooperation The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest. Foreign Aid,Treaties,Aid, Foreign,Cooperation, International,Treaty
D011786 Quality Control A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed) Control, Quality,Controls, Quality,Quality Controls
D012015 Reference Standards A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy. Standard Preparations,Standards, Reference,Preparations, Standard,Standardization,Standards,Preparation, Standard,Reference Standard,Standard Preparation,Standard, Reference
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014944 World Health Organization A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples. Organization, World Health,WHO

Related Publications

J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
A new international reference preparation for proteins in human serum.
January 1993, Archives of pathology & laboratory medicine,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
Why a new international reference preparation (IRP) for human plasma proteins?
January 1993, Journal of clinical laboratory analysis,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
Manufacture and characterization of a new reference preparation for 14 plasma proteins/CRM 470 = RPPHS lot 5.
January 1994, Journal of clinical laboratory analysis,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
International reference preparation for human serum IgG, IgA, IgM.
November 1974, Immunochemistry,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
International reference preparation for human serum IgG, IgA, IgM.
August 1974, Clinical and experimental immunology,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
An International Reference Preparation for human serum immunoglobulin E.
January 1973, Bulletin of the World Health Organization,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
Progress towards international reference standards for human serum proteins.
January 1978, Journal of biological standardization,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
Preparation and calibration of a reference preparation for human serum proteins.
February 1984, Clinical biochemistry,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
Letter: International reference preparation for human serum IgG, IgA, IgM.
January 1974, International archives of allergy and applied immunology,
J T Whicher, and R F Ritchie, and A M Johnson, and S Baudner, and J Bienvenu, and S Blirup-Jensen, and A Carlstrom, and F Dati, and A M Ward, and P J Svendsen
International reference preparation for anti-measles serum.
March 1992, Biologicals : journal of the International Association of Biological Standardization,
Copied contents to your clipboard!