BIOMAT Database Logo BIOMAT Database Logo

De novo design of beta-sheet proteins. 1994

M H Hecht
Department of Chemistry, Princeton University, NJ 08544-1009.

UI MeSH Term Description Entries
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D006860 Hydrogen Bonding A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds. Hydrogen Bonds,Bond, Hydrogen,Hydrogen Bond
D015202 Protein Engineering Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes. Genetic Engineering of Proteins,Genetic Engineering, Protein,Proteins, Genetic Engineering,Engineering, Protein,Engineering, Protein Genetic,Protein Genetic Engineering
D017433 Protein Structure, Secondary The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to ALPHA-HELICES; BETA-STRANDS (which align to form BETA-SHEETS), or other types of coils. This is the first folding level of protein conformation. Secondary Protein Structure,Protein Structures, Secondary,Secondary Protein Structures,Structure, Secondary Protein,Structures, Secondary Protein

Related Publications

M H Hecht
De novo design of monomeric beta-hairpin and beta-sheet peptides.
January 2006, Methods in molecular biology (Clifton, N.J.),
M H Hecht
De novo design of small beta barrel proteins.
March 2023, Proceedings of the National Academy of Sciences of the United States of America,
M H Hecht
De novo design of a monomeric three-stranded antiparallel beta-sheet.
April 1999, Protein science : a publication of the Protein Society,
M H Hecht
De Novo-Designed β-Sheet Heme Proteins.
February 2021, Biochemistry,
M H Hecht
Beta-hairpins in proteins revisited: lessons for de novo design.
October 1997, Protein engineering,
M H Hecht
De novo design of catalytic proteins.
August 2004, Proceedings of the National Academy of Sciences of the United States of America,
M H Hecht
De novo design of beta-helical polypeptides.
June 2007, Growth factors (Chur, Switzerland),
M H Hecht
De novo design of integral membrane proteins.
December 1994, Nature structural biology,
M H Hecht
De Novo Design of Iron-Sulfur Proteins.
January 2017, Methods in enzymology,
M H Hecht
De novo design of membrane transport proteins.
October 2022, Proteins,
Copied contents to your clipboard!