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To examine the mechanisms by which thyroid hormone modulates the inotropic state of rat myocardium, we studied the effects of thyroid state on isolated rat left ventricular papillary muscle function and intracellular calcium transients in the baseline state and in response to calcium and isoproterenol. Marked differences in contractile state of papillary muscles from hypothyroid and thyroid hormone-treated rats seen under baseline conditions (1.0 mM bath calcium, 30 degrees C, stimulation rate 12/min) do not appear to be due to differences in intracellular calcium concentration ([Ca2+]i) or to changes in myofilament calcium sensitivity but correlate with shifts in myosin isozyme distribution. In response to superimposed inotropic interventions (calcium, 0.625-5.0 mM, or isoproterenol, 10(-8)-10(-6) M), myocardial thyroid state modulates peak [Ca2+]i and inotropy, both of which are increased in thyroid hormone-treated relative to hypothyroid myocardium. The change in inotropy appears to be proportional to peak [Ca2+]i, whether mediated directly by calcium or as a result of beta-adrenergic stimulation. Thus, whereas baseline differences between hypothyroid and thyroid hormone-treated myocardium appear to be due to differences in myosin isozymes and presumed changes in adenosinetriphosphatase activity and cross-bridge cycling, superimposed inotropic responses appear to be mediated by changes in [Ca2+]i.
O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
March 2006,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
July 2012,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
August 1986,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
January 1974,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
November 1990,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
April 1989,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
May 1990,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
O H Bing, and
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C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
July 2005,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
January 1996,
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O H Bing, and
N L Hague, and
C L Perreault, and
C H Conrad, and
W W Brooks, and
S Sen, and
J P Morgan
February 1987,
Proceedings of the Royal Society of London. Series B, Biological sciences,
