-transparent.png){kind=logo}
To examine the utility of the single-dose captopril test in detecting renovascular hypertension (RVHT), the authors measured peripheral plasma renin activity (PRA), before and thirty and sixty minutes after an oral dose of captopril (25 mg), in 28 patients with RVHT and 22 patients with high-renin essential hypertension (EHT) without renal artery stenosis who were consuming 8 grams of sodium chloride per day. There was considerable overlap of individual values in basal PRA between the two groups. Sixty minutes after captopril, PRA was higher in RVHT than in EHT patients (74.8 +/- 63.9 versus 15.1 +/- 11.9 ng/mL/hr, P < 0.01). With the cutoff point set at 16 ng/mL/hr, RVHT was detected with a sensitivity of 96% and a specificity of 77%. The discriminating power was also superior to that based on blood pressure response to angiotensin II analogue under sodium depletion, rapid-sequence intravenous pyelography, or renography. These results show that captopril-stimulated peripheral PRA is an adequate screening tool for detecting RVHT in a population with high-renin hypertension.
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
November 1993,
The Netherlands journal of medicine,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
January 1993,
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
January 1989,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
December 1990,
American journal of hypertension,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
September 1995,
Journal of human hypertension,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
March 1999,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
August 1971,
Das Deutsche Gesundheitswesen,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
December 1993,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
January 1989,
Kardiologia polska,
M Takata, and
K Yoshida, and
F Tomoda, and
S Oh-hashi, and
H Ueno, and
K Yasumoto, and
H Iida, and
S Sasayama
April 1988,
Diabetic medicine : a journal of the British Diabetic Association,
