Biomaterial Database

Inactivation of Bacillus cereus beta-lactamase by halogenated isoxazolylpenicillins. 1976

R Strom, and G Ravagnan, and V Salfi

Upon preincubation with halogenated isoxazolyl-penicillins, the activity of Bacillus cereus beta-lactamase is decreased by a factor proportional to the inhibitor concentration. This inactivation, which concerns essentially the catalytic rate constant of the enzyme, occurs only at or above 37 degrees C with cloxacillin and dicloxacillin, and even at 25 degrees C with flucloxacillin. The dependence of the inactivation rate upon inhibitor concentration is consistent, in the former case, with the occurrence of a bimolecular reaction, and in the latter case, with a bimolecular process followed by a monomolecular step.

UI	MeSH Term	Description	Entries
D007555	Isoxazoles	Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.	Isoxazole
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D010080	Oxazoles	Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.	Oxazole,1,3-Oxazolium-5-Oxides,Munchnones,1,3 Oxazolium 5 Oxides
D010406	Penicillins	A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)	Antibiotics, Penicillin,Penicillin,Penicillin Antibiotics
D004009	Dicloxacillin	One of the PENICILLINS which is resistant to PENICILLINASE.	Dichloroxacillin,Cilpen,Diclocil,Dicloxaciclin,Dicloxacillin Sodium,Dicloxacillin, Monosodium Salt, Anhydrous,Dicloxacillin, Monosodium Salt, Mono-Hydrate,Dicloxacycline,Dicloxsig,Distaph,Ditterolina,Dycill,Dynapen,InfectoStaph,Pathocil,Posipen,Sodium, Dicloxacillin
D001409	Bacillus cereus	A species of rod-shaped bacteria that is a common soil saprophyte. Its spores are widespread and multiplication has been observed chiefly in foods. Contamination may lead to food poisoning.
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor