-transparent.png){kind=logo}
A full-length cDNA encoding the guinea pig kappa opioid (dynorphin) receptor has been isolated. The deduced protein contains 380 aa and seven hydrophobic alpha-helices characteristic of the G protein-coupled receptors. This receptor is 90% identical to the mouse and rat kappa receptors, with the greatest level of divergence in the N-terminal region. When expressed in COS-7 cells, the receptor displays high affinity and stereospecificity toward dynorphin peptides and other kappa-selective opioid ligands such as U50, 488. It does not bind the mu- and delta-selective opioid ligands. The expressed receptor is functionally coupled to G protein(s) to inhibit adenylyl cyclase and Ca2+ channels. The guinea pig kappa receptor mRNA is expressed in many brain areas, including the cerebellum, a pattern that agrees well with autoradiographic maps of classical guinea pig kappa binding sites. Species differences in the pharmacology and mRNA distribution between the cloned guinea pig and rat kappa receptors may be worthy of further examination.
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
January 2000,
Neuroscience,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
July 1982,
The Journal of pharmacology and experimental therapeutics,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
April 1997,
The Journal of pharmacology and experimental therapeutics,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
January 2000,
DNA and cell biology,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
December 1997,
The Journal of pharmacology and experimental therapeutics,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
February 1984,
European journal of pharmacology,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
March 1995,
The Journal of biological chemistry,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
January 2022,
Handbook of experimental pharmacology,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
April 1988,
Neuroscience letters,
G X Xie, and
F Meng, and
A Mansour, and
R C Thompson, and
M T Hoversten, and
A Goldstein, and
S J Watson, and
H Akil
January 1983,
Peptides,
