Biomaterial Database

[Effect of neuraminidase on the adherence of S. mutans to salivary pellicle]. 1993

M W Fan

Hospital of Stomatology, Hubei Medical University, Wuhang.

The salivary glycoproteins have been showing to play a receptor role in the adherence of bacteria to surface of teeth. Sialic acid is believed to be an important component of the salivary glycoprotein which adsorb selectively on tooth surface. The purpose of this study was to investigate the effect of neuraminidase on the adherence of S. mutans to saliva-coated hydroxyapatite, and concomitantly to determine the content of free sialic acid. The results show significantly lower adherence of S. mutans to neuraminidase treated versus untreated salivary pellicle. Results from these studies suggested that sialic acid receptors may mediate adherence of S. mutans.

UI	MeSH Term	Description	Entries
D009439	Neuraminidase	An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)	Sialidase,Exo-alpha-Sialidase,N-Acylneuraminate Glycohydrolases,Oligosaccharide Sialidase,Exo alpha Sialidase,Glycohydrolases, N-Acylneuraminate,N Acylneuraminate Glycohydrolases,Sialidase, Oligosaccharide
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001422	Bacterial Adhesion	Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.	Adhesion, Bacterial,Adhesions, Bacterial,Bacterial Adhesions
D012463	Saliva	The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.	Salivas
D012794	Sialic Acids	A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.	N-Acetylneuraminic Acids,Acids, N-Acetylneuraminic,Acids, Sialic,N Acetylneuraminic Acids
D013295	Streptococcus mutans	A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
D044622	Dental Pellicle	A thin protein film on the surface of DENTAL ENAMEL. It is widely believed to result from the selective adsorption of precursor proteins present in SALIVA onto tooth surfaces, and to reduce microbial adherence to the TEETH.	Enamel Pellicle,Salivary Pellicle,Salivary Acquired Pellicle,Acquired Pellicle, Salivary,Pellicle, Dental,Pellicle, Enamel,Pellicle, Salivary,Pellicle, Salivary Acquired
D017886	Durapatite	The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.	Calcium Hydroxyapatite,Hydroxyapatite,Hydroxylapatite,Alveograf,Calcitite,Interpore-200,Interpore-500,Osprovit,Ossein-Hydroxyapatite Compound,Ossopan,Osteogen,Periograf,Hydroxyapatite, Calcium,Interpore 200,Interpore 500,Interpore200,Interpore500,Ossein Hydroxyapatite Compound