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The ability of interleukin 2 (IL-2) to stimulate p72syk activity in intact porcine peripheral blood lymphocytes was examined. We demonstrated that IL-2 activated p72syk in a time- and dose-dependent manner, for which its peak time and maximum responsive dose were 5 min and 100 U/ml, respectively. This activation was observed only in cytosolic fractions and not in membrane ones. However, IL-2 failed to induced calcium mobilization. Moreover, IL-2-inducible p72synk activation was not affected when extra- intracellular calcium was depleted. These data suggest that the IL-2 signaling pathway through p72syk in peripheral blood lymphocytes is different, at least in part, from other agonists, such as concanavalin A in polymorphonuclear neutrophils which can trigger both the activation of p72syk and intracellular calcium mobilization.
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
January 1988,
Lymphokine research,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
August 1988,
Immunology,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
July 1993,
Biochemical and biophysical research communications,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
January 1987,
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
September 1991,
Acta psychiatrica Scandinavica,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
March 1991,
Clinical and experimental immunology,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
February 1988,
Cancer,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
May 1988,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
December 1989,
Proceedings of the National Academy of Sciences of the United States of America,
S Qin, and
T Inazu, and
C Yang, and
K Sada, and
T Taniguchi, and
H Yamamura
January 1989,
Cellular and molecular biology,
