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Photochemotherapy denotes a therapeutic approach that is based on the interaction of light and a photoactive drug. This study describes the efficacy of photochemotherapy, using orally administered methoxsalen and long-wave ultraviolet light in 91 patients with severe, generalized psoriasis. Oral administration of methoxsalen was followed by exposure to a high-intensity long-wave ultraviolet light source, emitting a continuous spectrum between 320 and 390 nm (peak, 365 nm) and an energy of 5.6 to 7.5 mw/sq cm at 15 cm. There was complete clearing of 82 patients (90%), a 90% to 100% clearing in seven (8%), and a satisfactory improvement in two (2%). A paired comparison study in 54 patients showed photochemotherapy to be far more effective than ultraviolet light emitted by fluorescent bulbs or a xenon source. Eighty-five percent of the patients receiving outpatient maintenance treatment have remained in remission for periods up to 400 days.
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
November 1979,
Archives of dermatology,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
September 1980,
International journal of dermatology,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
July 1981,
American journal of hospital pharmacy,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
December 1974,
The New England journal of medicine,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
March 1979,
The British journal of dermatology,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
April 1979,
The New England journal of medicine,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
April 1979,
Cancer treatment reports,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
January 1976,
Przeglad dermatologiczny,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
November 1977,
Archives of dermatology,
K W Wolff, and
T B Fitzpatrick, and
J A Parrish, and
F Gschnait, and
B Gilchrest, and
H Hönigsmann, and
M A Pathak, and
L Tannenbaum
June 1977,
The Journal of investigative dermatology,
