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In order to asses the effect of acute exposure to natural high altitude on some immunological mechanisms of mice, the primary response to SRBC was studied by the direct Hemolytic Plaque and Hemagglutination Tests. A control group was studied in Lima, Peru, 150 m. At high altitude (Ticlio, Peru, 4843 m), we found fewer spleen plaque-forming cells (PFC) and the maximal peak of PFC was delayed 1 day, as compared with the response at a lower altitude. Conversely, there was a higher serum concentration of 2-ME sensitive and resistant hemagglutinin antibodies at high altitude and the 19-S (2-ME sensitive) response was predominant during the first days at high altitude while the 7-S response was retarded. These results are interpreted as a stimulating effect of hypoxia on the 19-S antibody production rather than a cellular proliferation as far as the SRBC system is concerned. Serum concentrations of Igs G, M, A and the fraction C'3 of the Complement (B1C/B1A globulin) were determined in normal natives from three cities at different altitude levels: Morococha-Ticlio, 4680 m; La Oroya, 3700 m; and Tarma, 3051 m by the Radial Immunodiffusion Test. The serum concentration of C'3 was correlated with the total hemolytic activity of Complement (C'H50 method) in a group of natives from Morococha. The control group was of normal natives from Lima. No significant differences were found between resum concentration of Igs G, M and A in both groups, but there was a tendency for higher values of IgA at higher altitudes, and most sera in the high altitude group were above the normal IgG values for adults. The resum concentration of C'3 and the hemolytic activity of Complement were wound to be diminished in the high altitude group. These results are interpreted as an inhibitory effect of the altitude on the sequential activation and/or lysing capability rather than a reduction in the C'3 concentration.
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
October 1980,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
February 1977,
The Journal of tropical medicine and hygiene,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
March 2011,
Journal of the Royal Army Medical Corps,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
January 1978,
Zdravookhranenie Kirgizii,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
June 1965,
Canadian journal of microbiology,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
June 1988,
The International journal of neuroscience,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
May 1983,
No to shinkei = Brain and nerve,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
January 2004,
Wilderness & environmental medicine,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
December 1950,
Journal des praticiens; revue generale de clinique et de therapeutique,
L R Lopez, and
R A Cantella, and
Z Piscoya, and
A A Colichon, and
M Delgado, and
S Recavarren
March 1965,
The American journal of pathology,
