-transparent.png){kind=logo}
High-performance liquid chromatography (HPLC) was used for the therapeutic drug monitoring of quinidine in clinical samples. Solid-phase extraction (SPE) was studied in both off-line and on-line modes. SPE was performed in an automatic on-line mode using a fully automated Prospekt system. Extraction recoveries were in the range 97.1-99.4% for 1-2 micrograms/ml quinidine concentrations. For HPLC separation an Ultrasep RP-8 reversed-phase column was applied with acetonitrile-water (9:1) containing 0.3% triethylamine (pH 2.5) as the mobile phase. The Prospekt system is recommended for the routine monitoring of quinidine in plasma samples. Concentrations were in therapeutic range (1.2-3.6 micrograms/ml).
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
September 1990,
Biomedical chromatography : BMC,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
November 1997,
Yao xue xue bao = Acta pharmaceutica Sinica,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
November 1992,
International journal of clinical pharmacology, therapy, and toxicology,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
November 2001,
Journal of chromatography. B, Biomedical sciences and applications,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
July 2003,
Analytical and bioanalytical chemistry,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
June 1991,
Journal of chromatography,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
May 1993,
Journal of chromatography,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
January 1994,
Biomedical chromatography : BMC,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
March 1991,
Therapeutic drug monitoring,
E Brandsteterová, and
D Romanová, and
D Králiková, and
L Bozeková, and
M Kriska
April 1996,
Journal of chromatography. B, Biomedical applications,
