Biomaterial Database

Major surface glycoproteins of procyclic stage African trypanosomes. 1994

C E Stebeck, and T W Pearson

Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.

The procyclic stage in the life cycle of African trypanosomes is adapted for life in the harsh environment of the midgut of the tsetse fly vector. Procyclic forms derived by transformation from antigenically distinct bloodstream variants are antigenically similar and have lost the variant surface glycoprotein coat of the bloodstream forms. In contrast to bloodstream forms, where the variant surface glycoprotein coat is essentially the only molecule exposed, many different proteins can be labeled by surface iodination or biotinylation of procyclic trypanosomes. Despite this multiplicity of procyclic surface proteins, only a few have been characterized in any detail. This minireview focuses on one set of them, the predominant procyclins.

UI	MeSH Term	Description	Entries
D007303	Insect Vectors	Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.	Insect Vector,Vector, Insect,Vectors, Insect
D008562	Membrane Glycoproteins	Glycoproteins found on the membrane or surface of cells.	Cell Surface Glycoproteins,Surface Glycoproteins,Cell Surface Glycoprotein,Membrane Glycoprotein,Surface Glycoprotein,Glycoprotein, Cell Surface,Glycoprotein, Membrane,Glycoprotein, Surface,Glycoproteins, Cell Surface,Glycoproteins, Membrane,Glycoproteins, Surface,Surface Glycoprotein, Cell,Surface Glycoproteins, Cell
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014346	Trypanosoma brucei brucei	A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).	Trypanosoma brucei,Trypanosoma brucei bruceus,Trypanosoma bruceus,brucei brucei, Trypanosoma,brucei, Trypanosoma brucei,bruceus, Trypanosoma,bruceus, Trypanosoma brucei
D014348	Trypanosoma congolense	A species of Trypanosome hemoflagellates that is carried by tsetse flies and causes severe anemia in cattle. These parasites are also found in horses, sheep, goats, and camels.	Trypanosoma (Nannomonas) congolense,Trypanosoma congolenses,congolense, Trypanosoma
D014370	Tsetse Flies	Bloodsucking flies of the genus Glossina, found primarily in equatorial Africa. Several species are intermediate hosts of trypanosomes.	Glossina,Flies, Tsetse,Fly, Tsetse,Glossinas,Tsetse Fly
D014643	Variant Surface Glycoproteins, Trypanosoma	Glycoproteins attached to the surface coat of the trypanosome. Many of these glycoproteins show amino acid sequence diversity expressed as antigenic variations. This continuous development of antigenically distinct variants in the course of infection ensures that some trypanosomes always survive the development of immune response to propagate the infection.	Surface Variant Glycoproteins, Trypanosoma,Trypanosoma Variant Surface Coat Glycoproteins,SSP-4,VSG 117,VSG 118,VSG 221
D015800	Protozoan Proteins	Proteins found in any species of protozoan.	Proteins, Protozoan