Biomaterial Database

[Formation of iodotyrosines and iodothyronines in low iodinated human thyroglobulin fractionated by isopycnic ultracentrifugation]. 1976

A Vignal, and B Nataf

Iodotyrosines and iodothyronines formation have been studied in thyroglobulins (Tg) extracted from porrly iodinated human thyroid tissues. After centrifugation in RbCl density gradient, various protein fractions containing different amounts of iodine have been isolated from pure Tg. The results indicate that, even after fractionation of Tg, the synthesis of thyroid hormones takes place at a very low level of iodine content. This suggests that the Tg fractions are still heterogenous and contain a large proportion of non-iodinated molecules.

UI	MeSH Term	Description	Entries
D007455	Iodine	A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.	Iodine-127,Iodine 127
D007470	Monoiodotyrosine	A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.	Iodotyrosine
D002500	Centrifugation, Isopycnic	A technique used to separate particles according to their densities in a continuous density gradient. The sample is usually mixed with a solution of known gradient materials and subjected to centrifugation. Each particle sediments to the position at which the gradient density is equal to its own. The range of the density gradient is usually greater than that of the sample particles. It is used in purifying biological materials such as proteins, nucleic acids, organelles, and cell types.	Isopycnic Centrifugation
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013954	Thyroglobulin
D013963	Thyroid Hormones	Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.	Thyroid Hormone,Hormone, Thyroid,Hormones, Thyroid
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In