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Pemphigoid gestationis (PG; herpes gestationis) is a rare autoimmune disease associated with pregnancy, currently defined by the presence of complement deposition along the cutaneous basement membrane zone. It is known to be associated with HLA-DR3 and DR4, and an increase in anti-HLA antibodies in those with a history of PG has been reported. We have studied 39 patients with an immunofluorescence-confirmed diagnosis of PG for the presence and specificity of anti-HLA antibodies. Anti-HLA antibodies were found in all 39 patients. Specificity was against class I antigens in 98% (controls 10%; P < 0.001) and class II antigens in 25% (controls 8.5%; P < 0.001). Almost all anti-HLA antibodies were cytotoxic. The universal presence of anti-HLA antibodies in PG suggests that they may develop coincidently with antibasement membrane antibodies, and may reflect a common immunological event.
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
December 2014,
Journal of obstetrics and gynaecology of India,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
January 1987,
Indian journal of dermatology, venereology and leprology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
January 2006,
Clinics in dermatology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
November 1983,
The Journal of investigative dermatology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
June 1988,
Seminars in dermatology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
May 1981,
The British journal of dermatology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
April 1992,
Journal of the American Academy of Dermatology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
January 1984,
The British journal of dermatology,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
May 2015,
Cutis,
J K Shornick, and
R E Jenkins, and
D C Briggs, and
K I Welsh, and
S E Kelly, and
M P Garvey, and
M M Black
January 1994,
Dermatology (Basel, Switzerland),
