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A molecular cytogenetic approach that facilitates high-resolution comparative mapping of defined human genes in different primate species is presented. Fluorescence in situ hybridization and digital imaging microscopy were used to visualize human DNA probes on simultaneously banded or "painted" metaphase chromosomes of great apes (Pan troglodytes, Gorilla gorilla, Pongo pygmaeus), hylobatids (Hylobates lar and Hylobates syndactylus), and Old World monkeys (Macaca fuscata and Cercopithecus aethiops). Using a series of DNA probes, chromosomal rearrangements in the karyotypes of primates were readily detected at the molecular cytogenetic level. This approach should contribute considerably to the understanding of primate phylogeny and evolution.
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
February 1999,
Genomics,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
March 1994,
Cytometry,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
January 1996,
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
March 1999,
The Plant journal : for cell and molecular biology,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
January 2000,
Cytogenetics and cell genetics,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
January 1995,
Cytogenetics and cell genetics,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
April 1996,
Annals of medicine,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
January 2002,
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
May 2006,
Biology of reproduction,
T Ried, and
N Arnold, and
D C Ward, and
J Wienberg
January 2017,
Methods in molecular biology (Clifton, N.J.),
