Biomaterial Database

Species differences in the metabolism of aflatoxin B1. 1976

P O Emafo

The metabolism of aflatoxin B1 in a number of animals was investigated. Aflatoxin B1 is metabolized relatively more slowly in liver slices of sheep than in the mouse, goat, guinea-pig, rabbit and golden hamster. The rate of metabolism of the toxin by the 10,000 g supernatant is faster than the metabolism by liver slices. This may be as a result of the substrate not penetrating the liver cells readily. Species difference exist in the in vitro metabolism of aflatoxin B1 by hydroxylation and demethylation. The sheep and White Rock cockerel demethylate aflatoxin B1 poorly but the dog and duck do not demethylate the toxin at all. Of the animals studied, the duck, mouse and White Rock cockerel do not produce aflatoxin M1 at all. The sheep and dog produce aflatoxin M1 in comparatively large amounts, while the rat, goat and golden hamster produce aflatoxin M1 in smaller quantities.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D011200	Poultry	Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.	Fowls, Domestic,Domestic Fowl,Domestic Fowls,Fowl, Domestic,Poultries
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006041	Goats	Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.	Capra,Capras,Goat
D000348	Aflatoxins	Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.	Aflatoxin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012377	Rodentia	A mammalian order which consists of 29 families and many genera.	Beavers,Capybaras,Castor Beaver,Dipodidae,Hydrochaeris,Jerboas,Rodents,Beaver,Capybara,Hydrochaeri,Jerboa,Rodent,Rodentias