-transparent.png){kind=logo}
Changes in gastric contractility following lateral hypothalamic (LH) lesions with and without bilateral cervical vagotomy were measured in urethan-anesthetized rats. LH lesions were induced with direct current passed through stereotaxically placed electrodes. Gastric contractility was recorded continuously for 4 h with acutely implanted strain gauge force transducers and analyzed by computer. LH lesions consistently stimulated gastric contractility and caused more gastric mucosal injury than control conditions. Vagotomy blocked both gastric mucosal injury and high-amplitude gastric contractions. In rats with LH lesions and exogenously infused intragastric hydrochloric acid, atropine methyl nitrate inhibited high-amplitude gastric contractions and gastric erosions. These findings indicate that LH lesions stimulate vagally mediated high-amplitude gastric contractions, which, in the presence of hydrochloric acid, cause gastric mucosal erosions.
T Garrick, and
C V Grijalva, and
M Trauner
January 1995,
Journal of gastroenterology and hepatology,
T Garrick, and
C V Grijalva, and
M Trauner
January 1970,
Acta neurobiologiae experimentalis,
T Garrick, and
C V Grijalva, and
M Trauner
April 1980,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T Garrick, and
C V Grijalva, and
M Trauner
February 1976,
Journal of comparative and physiological psychology,
T Garrick, and
C V Grijalva, and
M Trauner
April 1983,
Brain research bulletin,
T Garrick, and
C V Grijalva, and
M Trauner
November 1982,
Life sciences,
T Garrick, and
C V Grijalva, and
M Trauner
February 1975,
Physiology & behavior,
T Garrick, and
C V Grijalva, and
M Trauner
March 1991,
Behavioral and neural biology,
T Garrick, and
C V Grijalva, and
M Trauner
March 1962,
Psychological review,
T Garrick, and
C V Grijalva, and
M Trauner
October 1970,
Journal of neurology, neurosurgery, and psychiatry,
