-transparent.png){kind=logo}
A new series of piperidineacrylate derivatives was prepared and evaluated for antiallergic activity. Most of the compounds showed potent activities in the rat passive cutaneous anaphylaxis (PCA) assay. In particular, ethyl 1-[2-bis(4-fluorophenyl)methoxyethyl]-4-piperidineacrylate (1a) was more potent than oxatomide and terfenadine in this assay, and was selected for further study. Some pharmacological properties of 1a are presented.
Related Publications
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
July 1974,
Journal of medicinal chemistry,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
June 1989,
Journal of medicinal chemistry,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
October 1977,
Journal of medicinal chemistry,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
May 1978,
Journal of pharmaceutical sciences,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
March 1992,
Journal of medicinal chemistry,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
July 1991,
Journal of medicinal chemistry,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
October 2022,
Molecules (Basel, Switzerland),
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
January 2016,
Current pharmaceutical design,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
July 2022,
Pharmaceutics,
M Sugiyama, and
T Sakamoto, and
Y Kamigaki, and
H Fukumi, and
K Itoh, and
Y Satoh, and
T Yamaguchi
February 1994,
Farmaco (Societa chimica italiana : 1989),
