-transparent.png){kind=logo}
Novel indolecarboxamidotetrazoles as potential antiallergy agents. 1989
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
The synthesis and antiallergic potential of a series of novel indolecarboxamidotetrazoles are described. A number of compounds inhibit the release of histamine from anti-IgE-stimulated basophilic leukocytes obtained from allergic donors. Optimal inhibition is exhibited by compounds with 3-alkoxy, 5-methoxy, and 1-phenyl substituents on the indole core structure. Compound 8d (5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H -indole-2-carboxamide; designated CI-949) is a potent inhibitor of histamine release from human basophils and from guinea pig and human chopped lung.
Related Publications
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
July 1991,
Journal of medicinal chemistry,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
May 1993,
Chemical & pharmaceutical bulletin,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
May 1978,
Journal of pharmaceutical sciences,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
July 1974,
Journal of medicinal chemistry,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
January 1997,
Terapevticheskii arkhiv,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
January 1997,
Acta poloniae pharmaceutica,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
January 1980,
Journal of medicinal chemistry,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
October 1977,
Journal of medicinal chemistry,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
January 1999,
Acta poloniae pharmaceutica,
P C Unangst, and
D T Connor, and
S R Stabler, and
R J Weikert, and
M E Carethers, and
J A Kennedy, and
D O Thueson, and
J C Chestnut, and
R L Adolphson, and
M C Conroy
September 1978,
Journal of medicinal chemistry,
