Cadmium, zinc, copper, and metallothionein levels in the kidney and liver of inhabitants of upper Silesia (Poland). 1993

E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
Department of Toxicological Chemistry, Medical University, Lodz, Poland.

The levels of Cd, Zn, Cu and metallothionein (MT) were determined in renal cortex and liver of 75 subjects decreased in the period 1986-1989 in the area of Upper Silesia (Katowice). The mean age of the population studied was 53.6 +/- 14.6 years. The determined levels (mean +/- SD) were: 43.1 +/- 23.5 micrograms Cd/g; 52.5 +/- 17.4 micrograms Zn/g; 2.2 +/- 0.7 microgram Cu/g; 0.80 +/- 0.36 mumol Hg/g in renal cortex and 3.5 +/- 2.5 micrograms Cd/g; 82.8 +/- 34.3 micrograms Zn/g; 4.5 +/- 2.6 micrograms Cu/g; 0.69 +/- 0.44 mumol Hg/g in the liver. The level of Cd in renal cortex was 40% higher in smokers compared to nonsmokers and was independent of the gender. Whole-body retention of Cd was 34.1 +/- 18.5 mg; smoking elevated the value from 27.1 to 38.2 mg. Compared with a similar study made in central Poland (Lódź), a significant difference was found only regarding the level of Zn and MT in the liver, pointing to the possibility that exposure to this element in the region of Upper Silesia may be higher.

UI MeSH Term Description Entries
D007672 Kidney Cortex The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL. Cortex, Kidney
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008668 Metallothionein A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals. Isometallothionein,Metallothionein A,Metallothionein B,Metallothionein I,Metallothionein II,Metallothionein IIA
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011044 Poland A country in central Europe, east of Germany. The capital is Warsaw. Polish People's Republic,Republic of Poland
D002104 Cadmium An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
D003300 Copper A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55. Copper-63,Copper 63
D004781 Environmental Exposure The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals. Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D005260 Female Females

Related Publications

E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
January 1989, Toxicology letters,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
March 1993, Environmental monitoring and assessment,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
January 1988, International archives of occupational and environmental health,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
January 1993, Polish journal of occupational medicine and environmental health,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
December 1979, Environmental research,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
September 1992, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
October 1981, Environmental research,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
January 2002, Biological trace element research,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
January 1987, Experientia. Supplementum,
E M Bem, and C Orlowski, and J K Piotrowski, and K Januszewski, and J Pajak
April 1987, Environmental research,
Copied contents to your clipboard!