Inhibition of DNA synthesis in BHK fibroblasts treated in vitro with potassium dichromate. 1977

A G Levis, and M Buttignol, and L Vettorato

Treatment of hamster fibroblasts with potassium dichromate in vitro stimulates tritiated thymidine uptake into the intracellular nucleotide pool. This effect is due to the oxidizing action of hexavalent chromium on the plasma membrane. Dichromate, induces also an inhibition of DNA replication, which is due to the interaction of reduced trivalent chromium with specific biological ligands on the DNA molecule.

UI MeSH Term Description Entries
D011192 Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison. Potassium Bichromate,K2Cr2O7,Bichromate, Potassium,Dichromate, Potassium
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002840 Chromates Salts of chromic acid containing the CrO(2-)4 radical. Chromate
D003864 Depression, Chemical The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Depression,Chemical Depressions,Depressions, Chemical
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D013936 Thymidine A nucleoside in which THYMINE is linked to DEOXYRIBOSE. 2'-Deoxythymidine,Deoxythymidine,2' Deoxythymidine
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

A G Levis, and M Buttignol, and L Vettorato
February 1979, Chemico-biological interactions,
A G Levis, and M Buttignol, and L Vettorato
November 1997, Mutagenesis,
A G Levis, and M Buttignol, and L Vettorato
April 1970, American journal of diseases of children (1960),
A G Levis, and M Buttignol, and L Vettorato
September 1985, Wiadomosci lekarskie (Warsaw, Poland : 1960),
A G Levis, and M Buttignol, and L Vettorato
January 1970, Przeglad lekarski,
A G Levis, and M Buttignol, and L Vettorato
January 1977, Comptes rendus des seances de la Societe de biologie et de ses filiales,
A G Levis, and M Buttignol, and L Vettorato
October 1993, Archives of biochemistry and biophysics,
A G Levis, and M Buttignol, and L Vettorato
April 1979, Nature,
A G Levis, and M Buttignol, and L Vettorato
January 1980, Przeglad dermatologiczny,
Copied contents to your clipboard!