-transparent.png){kind=logo}
OBJECTIVE To assess the expression of Cu,Zn-SOD and Mn-SOD in peritoneal fluid and ectopic endometrium from women with adenomyosis. METHODS The levels of Cu,Zn-SOD and Mn-SOD were measured in peritoneal fluid from infertile women who did not have endometriosis (n = 27), women with adenomyosis (n = 22), and women with endometriosis (n = 15). The expression of Cu,Zn-SOD and Mn-SOD messenger ribonucleic acids in ectopic endometrium was investigated by Northern blot analysis. Mn-SOD in ectopic endometrium was investigated by immunohistochemical staining. RESULTS The levels of Cu,Zn-SOD and Mn-SOD were significantly higher in the peritoneal fluid from women with adenomyosis than in those with endometriosis or infertile women. Mn-SOD was highly expressed in ectopic endometrium, but Cu,Zn-SOD was not. Mn-SOD was detected in ectopic endometrium of women with adenomyosis. CONCLUSIONS These data show that reactive oxygen produced in adenomyosis may induce Mn-SOD in ectopic endometrium, which results in the release of relatively large amounts of this protein into the peritoneal fluid. These results suggest that free radicals may play a role in the pathogenesis of adenomyosis, the same as they do in other inflammatory processes.
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
August 2002,
Nihon rinsho. Japanese journal of clinical medicine,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
August 1999,
Nihon rinsho. Japanese journal of clinical medicine,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
June 1992,
Sangre,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
August 2013,
BMB reports,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
March 1998,
Burns : journal of the International Society for Burn Injuries,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
June 1993,
Rinsho byori. The Japanese journal of clinical pathology,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
January 1977,
Journal of applied physiology: respiratory, environmental and exercise physiology,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
July 1999,
Fertility and sterility,
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
January 2024,
Methods in molecular biology (Clifton, N.J.),
M Ishikawa, and
T Nakata, and
Y Yaginuma, and
K Nishiwaki, and
K Goishi, and
S Saitoh
June 2003,
American journal of physiology. Lung cellular and molecular physiology,
