Porphyromonas gingivalis adheres in vitro to biofilms containing Streptococcus and Actinomyces species. On initial entry to the mouth, this interbacterial adhesion may enable P. gingivalis to colonize dental plaque and to avoid clearance by saliva flow. Saliva may also interfere directly with P. gingivalis colonization of dental plaque; a 43-kDa glycoprotein in human submandibular-sublingual saliva binds to P. gingivalis surfaces and diminishes interbacterial adhesion activity. To avoid fouling of its surface by host components, P. gingivalis produces surface-localized proteases that can degrade adsorbed proteins and may serve to unmask bacterial adhesins. Successful management of P. gingivalis colonization might be achieved in the future by devising artificial methods to block its surface adhesins or to prevent bacterial proteolysis of native salivary molecules that have protective functions.