-transparent.png){kind=logo}
Bright light bleaches visual pigment and leads to a persistent desensitization of isolated rod and cone photoreceptors called bleaching adaptation. Bleaching adaptation results from the combined effects of pigment depletion and adaptational modulation of certain cellular reactions in the visual transduction cascade. Here, we present evidence that in solitary cone photoreceptors isolated from the salamander retina, the latter effect is due to the presence of free opsin in the outer segment. Also, we demonstrate that this "opsin adaptation" can be reversed by treating the cells with synthetic retinoids similar to 11-cis retinal but having polyene chains too short to form protonated Schiff base attachments to opsin.
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
January 2008,
Photochemistry and photobiology,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
March 2001,
Neuron,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
September 1993,
The Journal of general physiology,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
October 1996,
The Journal of comparative neurology,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
March 1999,
Proceedings of the National Academy of Sciences of the United States of America,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
March 1999,
The Journal of general physiology,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
July 1988,
Nature,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
January 1969,
Archives d'ophtalmologie et revue generale d'ophtalmologie,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
April 1999,
Biophysical chemistry,
J Jin, and
R K Crouch, and
D W Corson, and
B M Katz, and
E F MacNichol, and
M C Cornwall
September 1981,
The Journal of physiology,
