-transparent.png){kind=logo}
In 82 patients with stage III malignant melanoma, the primary tumours were investigated by DNA flow cytometry. The tumours were classified as DNA diploid (n = 36), tetraploid (n = 11) and aneuploid (n = 35). By univariate analysis a significant correlation with post-recurrence survival was found for time to first metastasis, DNA-ploidy and S-phase fraction. By multivariate analysis, significant prognostic variables were found to be the time to first metastasis (P = 0.006), and ploidy (P = 0.011). Patients with diploid melanomas and a long recurrence-free interval had a median post-recurrence survival time of 45 months compared to 18 months in patients with DNA aneuploid tumours and an early recurrence. The S-phase could be estimated in 47 primary melanomas and was found to be a significant prognostic variable (P = 0.017). The median survival was 45 months for patients with melanomas with a S-phase fraction below 5%, and 19 months for melanomas with S-phase above 10%. The prognostic value of the S-phase remained significant even after adjustment for recurrence-free interval and DNA ploidy.
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
February 2000,
Canadian journal of surgery. Journal canadien de chirurgie,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
January 1994,
Cancer treatment and research,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
June 1998,
British journal of cancer,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
September 1990,
The Japanese journal of surgery,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
February 2019,
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
January 1998,
Oncology reports,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
August 1995,
Gynecologic oncology,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
January 1997,
Anticancer research,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
December 1997,
Analytical and quantitative cytology and histology,
M Karlsson, and
B Boeryd, and
J Carstensen, and
B Kågedal, and
A T Bratel, and
S Wingren
March 2000,
The European journal of surgery = Acta chirurgica,
