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Clinical data from 369 patients with clinical stage I cutaneous malignant melanoma treated in Kuopio University Hospital district between 1974 and 1989 with a mean follow-up of 6.4 years were analysed. Clinical parameters, histology, DNA index, S-phase fraction (SPF) and mitotic indices [mitotic activity index (MAI) and volume-corrected mitotic index (M/V index)] were correlated with the outcome of the disease to establish their value as predictors of stage I cutaneous malignant melanoma. In univariate survival analyses, bleeding, gender, tumour thickness, level of invasion according to Clark, TNM category, MAI, M/V index and SPF were the most significant predictors of recurrence-free (RFS) and overall survival. In Cox's multivariate analysis, tumour thickness (P = 0.0021), bleeding (P = 0.0106) and M/V index (P = 0.0058) predicted poor RFS in the 259 patients available for the analysis. Poor overall survival was predicted by MAI (P = 0.0002), bleeding (P = 0.004), SPF (P = 0.009) and male gender (P = 0.034). The present results indicate that mitotic activity index (MAI), volume-corrected mitotic index (M/V index) and S-phase fraction (SPF) are important prognostic factors in addition to the well-established Breslow thickness in stage I cutaneous malignant melanoma.
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
February 2000,
Canadian journal of surgery. Journal canadien de chirurgie,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
October 2019,
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
January 1993,
British journal of cancer,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
June 1983,
Cancer research,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
January 1978,
Scandinavian journal of plastic and reconstructive surgery,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
September 1984,
Analytical and quantitative cytology,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
September 1993,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
May 1990,
The Journal of dermatologic surgery and oncology,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
May 1994,
Cancer,
J M Karjalainen, and
M J Eskelinen, and
S Nordling, and
P K Lipponen, and
E M Alhava, and
V M Kosma
December 2002,
Pathologica,
