Biomaterial Database

Genetic sensitivity to thiamine deficiency and development of alcoholic organic brain disease. 1993

P R Martin, and B A McCool, and C K Singleton

Department of Psychiatry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232.

UI	MeSH Term	Description	Entries
D001925	Brain Damage, Chronic	A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.	Encephalopathy, Chronic,Chronic Encephalopathy,Chronic Brain Damage
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000425	Alcohol Amnestic Disorder	A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)	Alcohol-Induced Amnestic Syndrome,Amnestic Psychosis, Alcohol-Induced,Alcohol Amnestic Syndrome,Alcohol-Induced Amnestic Psychosis,Alcohol-Induced Dysmnesic Psychosis,Alcohol-Induced Dysmnesic Syndrome,Alcohol-Induced Persisting Amnestic Disorder,Alcohol Amnestic Disorders,Alcohol Amnestic Syndromes,Alcohol Induced Amnestic Psychosis,Alcohol Induced Amnestic Syndrome,Alcohol Induced Dysmnesic Psychosis,Alcohol Induced Dysmnesic Syndrome,Alcohol Induced Persisting Amnestic Disorder,Alcohol-Induced Amnestic Psychoses,Alcohol-Induced Amnestic Syndromes,Alcohol-Induced Dysmnesic Psychoses,Alcohol-Induced Dysmnesic Syndromes,Amnestic Disorder, Alcohol,Amnestic Psychoses, Alcohol-Induced,Amnestic Psychosis, Alcohol Induced,Amnestic Syndrome, Alcohol-Induced,Amnestic Syndromes, Alcohol-Induced,Dysmnesic Psychoses, Alcohol-Induced,Dysmnesic Psychosis, Alcohol-Induced,Dysmnesic Syndrome, Alcohol-Induced,Dysmnesic Syndromes, Alcohol-Induced,Psychoses, Alcohol-Induced Amnestic,Psychoses, Alcohol-Induced Dysmnesic,Psychosis, Alcohol-Induced Amnestic,Psychosis, Alcohol-Induced Dysmnesic
D000437	Alcoholism	A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)	Alcohol Abuse,Alcoholic Intoxication, Chronic,Ethanol Abuse,Alcohol Addiction,Alcohol Dependence,Alcohol Use Disorder,Abuse, Alcohol,Abuse, Ethanol,Addiction, Alcohol,Alcohol Use Disorders,Chronic Alcoholic Intoxication,Dependence, Alcohol,Intoxication, Chronic Alcoholic,Use Disorders, Alcohol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D013832	Thiamine Deficiency	A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)	Deficiency, Thiamine,Deficiencies, Thiamine,Thiamine Deficiencies
D014174	Transketolase	An enzyme of the transferase class that catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate in the PENTOSE PHOSPHATE PATHWAY. (Dorland, 27th ed) EC 2.2.1.1.	Apotransketolase,Glycolaldehydetransferase
D014899	Wernicke Encephalopathy	An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)	Beriberi, Cerebral,Encephalopathy, Wernicke,Encephalopathy, Gayet-Wernicke,Encephalopathy, Wernicke's,Gayet-Wernicke Encephalopathy,Wernicke Disease,Wernicke Polioencephalitis, Superior Hemorrhagic,Wernicke Superior Hemorrhagic Polioencephalitis,Wernicke Syndrome,Wernicke's Disease,Wernicke's Encephalopathy,Wernicke's Polioencephalitis, Superior Hemorrhagic,Wernicke's Superior Hemorrhagic Polioencephalitis,Wernicke's Syndrome,Cerebral Beriberi,Encephalopathies, Wernicke,Encephalopathy, Gayet Wernicke,Encephalopathy, Wernickes,Gayet Wernicke Encephalopathy,Wernicke Encephalopathies