Biomaterial Database

Milk cholesterol concentration in sows selected for three generations for high or low serum cholesterol. 1993

M M Kandeh, and Y W Park, and W G Pond, and L D Young

Cooperative Agricultural Research Center, Prairie View A&M University, TX 77446.

Female crossbred swine (Chester White x Landrace x Large White x Yorkshire) selected for three generations for low (L, n = 24) or high (H, n = 26) serum cholesterol at 8 wk of age were milked at d 20 or 21 of their first lactation to measure cholesterol, fat, lactose, protein, and ash concentrations. A contemporary, unselected control (C) group from the same original population (third lactation, n = 7) was sampled concurrently. All sows were fed a standard gestation, then lactation, diet that contained no cholesterol or added fat (all plant, corn-soybean meal). Genetic selection for low or high serum cholesterol at 8 wk of age induced corresponding changes in milk cholesterol and fat concentration in the third generation of selection, but not in any other milk constituents. Milk cholesterol concentrations (milligrams/100 grams fresh weight) were L, 25.3 +/- 3.0; C, 35.7 +/- 8.0; and H, 41.4 +/- 6.9 (L < C < H, P < .01). Corresponding values for milk fat were 5.7 +/- 1.3, 7.2 +/- .8, and 7.0 +/- .8 mg (L < C = H, P < .01). Serum cholesterol concentrations at 8 wk of age were L, 66.1 +/- 8.1; C, 93.7 +/- 13.7; and H, 126.2 +/- 9.7 mg/dL (P < .01). Milk cholesterol concentration was significantly correlated with serum cholesterol (r = .782, P < .01) and milk fat (r = .36, P < .01). It seems that selecting swine for low or high serum cholesterol at 8 wk of age induced changes in lipid metabolism reflected in differences in milk cholesterol concentrations.

UI	MeSH Term	Description	Entries
D007774	Lactation	The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.	Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008055	Lipids	A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)	Lipid
D008297	Male		Males
D008892	Milk	The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals.	Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D001947	Breeding	The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.	Breedings
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012641	Selection, Genetic	Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.	Natural Selection,Genetic Selection,Selection, Natural
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog