Biomaterial Database

Effect of dietary fat and cholesterol level on tissue cholesterol concentrations of growing pigs selected for high or low serum cholesterol. 1993

K B Harris, and H R Cross, and W G Pond, and H J Mersmann

Department of Animal Science, Texas A&M University, College Station 77843-2471.

Thirty-six female pigs selected for three generations for high or low serum cholesterol were chosen to evaluate the effects of a high-fat, high-cholesterol diet and a low-fat, low-cholesterol diet provided on an ad libitum basis for 92 d beginning at 12 wk of age on the cholesterol content and percentage of fat in muscle and organ tissues. The pigs were four-way crosses (Chester White x Landrace x Large White x Yorkshire). Samples of cerebrum, heart, ileum, kidney, liver, longissimus muscle, semitendinosus muscle, and subcutaneous fat were collected from each animal for determination of cholesterol concentration. The liver was the only tissue that had a significant difference in cholesterol content and in fat percentage between the genetic groups (high serum cholesterol and low serum cholesterol) and between the two diets (high-fat, high-cholesterol diet and low-fat, low-cholesterol diet). There were no interactions between diet and genetic background on cholesterol accretion or on the percentage of fat in the tissues.

UI	MeSH Term	Description	Entries
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008055	Lipids	A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)	Lipid
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D001923	Brain Chemistry	Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.	Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D001947	Breeding	The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.	Breedings
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D002791	Cholesterol, Dietary	Cholesterol present in food, especially in animal products.	Dietary Cholesterol