Effect of recombinant human transforming growth factor beta 1 on immune responses in patients with chronic hepatitis B. 1993

S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

Studies were undertaken to examine the effect of recombinant human transforming growth factor beta 1 (rTGF-beta 1) on cellular and humoral immune responses of peripheral blood mononuclear cells (PBMC) from patients with chronic hepatitis B. The addition of TGF-beta 1 caused a significant dose-dependent inhibition of hepatitis B (HB) core Ag-stimulated interferon-gamma and antibody to HB core Ag production and proliferation of PBMC from chronic hepatitis patients and HB-immune donors. TGF-beta 1 also induced a significant reduction in pokeweed mitogen-stimulated IgG and IgM production, as well as phytohemagglutinin p-stimulated proliferative response of PBMC. The degree of inhibition of TGF-beta 1 did not differ between antigen-specific and -nonspecific cellular and humoral immune responses, and between control individuals and patients. Pretreatment study with TGF-beta 1 showed that the activities of T cells, B cells and monocytes were similarly inhibited. Further, TGF-beta 1 inhibited activities of HLA class I antigen-matched cytotoxic T cells from patients with chronic hepatitis B for HBV DNA-transfected HepG2 cells in a 51Cr release assay. The results suggest that TGF-beta 1 may play a role in the regulation of antigen-dependent and -independent immune responses in patients with chronic hepatitis B.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008297 Male Males
D003602 Cytotoxicity, Immunologic The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. Tumoricidal Activity, Immunologic,Immunologic Cytotoxicity,Immunologic Tumoricidal Activities,Immunologic Tumoricidal Activity,Tumoricidal Activities, Immunologic
D004306 Dose-Response Relationship, Immunologic A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell. Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response
D005260 Female Females
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006510 Hepatitis B Antibodies Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the "e" antigens. Anti-Australia Antigens,Anti-HBAg,Anti-Hepatitis B Antigens,Anti HBAg,Hepatitis B Virus Antibodies,Anti Australia Antigens,Anti Hepatitis B Antigens,Antibodies, Hepatitis B,Antigens, Anti-Australia,Antigens, Anti-Hepatitis B,B Antibodies, Hepatitis,B Antigens, Anti-Hepatitis,HBAg, Anti
D006512 Hepatitis B Core Antigens The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion. HBcAg,Hepatitis B Core Antigen

Related Publications

S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
January 1997, Journal of viral hepatitis,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
July 1998, Journal of gastroenterology and hepatology,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
October 1998, Archives of physiology and biochemistry,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
May 2003, The Journal of craniofacial surgery,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
January 2006, Annual review of immunology,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
October 2003, Journal of gastroenterology and hepatology,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
April 1988, Cellular immunology,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
July 1996, The Journal of craniofacial surgery,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
January 1993, International review of experimental pathology,
S Kakumu, and Y Ito, and M Takayanagi, and K Yoshioka, and T Wakita, and T Ishikawa, and Y Higashi, and Z Q Yang
September 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
Copied contents to your clipboard!