-transparent.png){kind=logo}
Early colony stimulating factor-1 (CSF-1)-induced changes in the behavior of p120c-cbl in mouse BAC1.2F5 macrophages were investigated. p120c-cbl is associated with Grb2 in the cytoplasm of unstimulated cells. Following a 1-min stimulation with CSF-1, p120c-cbl becomes tyrosine-phosphorylated and associates with tyrosine-phosphorylated Shc and an unknown phosphotyrosyl protein (pp80). Simultaneously, it is ubiquitinated and translocated to the membrane. By 10 min of stimulation, this c-Cbl exhibits substantially decreased tyrosine phosphorylation and is de-ubiquitinated and relocated in the cytosol. However, the association of p120c-cbl with Shc persists for at least 60 min. These data indicate that signaling via the CSF-1R involves the transient modification of p120c-cbl and its recruitment as a complex to membrane.
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
November 2009,
BMC cell biology,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
October 1995,
Oncogene,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
December 1995,
Japanese journal of cancer research : Gann,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
October 1996,
The Journal of biological chemistry,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
November 1996,
The Biochemical journal,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
March 2001,
Biochemical and biophysical research communications,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
September 1995,
The Journal of biological chemistry,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
November 2004,
Cellular signalling,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
August 2000,
International journal of oncology,
Y Wang, and
Y G Yeung, and
W Y Langdon, and
E R Stanley
August 1995,
The Journal of experimental medicine,
